Journal Article and Summary

Journal Article:

journal.pntd.0005920

https://www.ncbi.nlm.nih.gov/pubmed/29190303

Scabies in the age of increasing drug resistance

Samar Khalil, Ossama Abbas,  Abdul Ghani Kibbi, Mazen Kurban

 

What is scabies?

  • Infestation of skin by human itch mite (Sarcoptes scabiei var. hominis)

Signs and Symptoms

  • Pruritic, pimple like papular rash
  • Rash can be tiny blisters vesicles and scales
  • Scratching may lead to skin sores
  • Sites like wrist, elbow, armpit, webbing between fingers, nipples, penis, waist, belt line, buttocks

How does one get scabies?

  • Spreads by direct, prolong, skin to skin contact with infected person
  • Frequently sexually acquired
  • Can be spread indirectly, sharing clothes, towels, or bedding with infested person

How to diagnose scabies?

  • Based on appearance and distribution of rash and presence of burrows
  • Confirm by identifying mite, mite eggs, or mite fecal matter

Scabies treatment

  • Scabiciides treat human scabies available with doctors prescription

Purpose

To review mechanisms of resistance proposed in literature and potential solutions to this problem.

Treatment

  • Topical
    • Permethrin
    • Lindane
    • Other
      • Crotamiton, Precipitated sulfure, benzylbenozate, malathion
    • Systemic
      • Ivermectin

Key Points/Conclusion

  • Scabies is one of the W.H.O list of neglected diseases
  • Resistance has increased throughout the years ,therefore newer methods of control needed
  • 4 mechanisms with potential solutions to resistance
  • More studies need to be done
  • Years for vaccine to be available

 

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