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Journal Family Medicine : Influenza

2 months ago

232 words

Journal Article
DOI: 10.1056/NEJMoa1716197
https://www.ncbi.nlm.nih.gov/pubmed/30184455
Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents.
What is influenza?
  • Viral infection also termed “flu” to describe respiratory or GI illness, it is a contagious that infects the nose, throat, sometimes lungs. It can cause mild to severe illness, and at times can lead to death. The best way to prevent flu is by getting vaccinated.
Signs and Symptoms
  • Fevers
  • Chills
  • Sore throat
  • muscle aches/body aches
  • head aches
  • runny or stuffy nose
  • fatigue
  • Cough
  • somestime diarrhea and vomitting
    • Lasts weeks 1 week or more
How does one gets the flu?
  • Spreads by tiny droplets, when people infected cough, sneeze or talk
  • Less likely, but touching surface or objects that flu virus on it and touching own mouth.
How to diagnose flu?
  • Rapid flu
  • Difficult to distinguish from other viral or bacterial URI
Scabies treatment
Purpose
To review baloxavir marboxil as a selective inhibitor of influenza cap-dependent endonuclease.
Key Points/Conclusion
  • Single doses of baloxavir (Xolfuza) superior to placebo in alleviating symptoms in patients with uncomplicated influenza, without any clinical significant side effects
  • The difference in time to alleviate between baloxavir and the placebo was greater in patients who began the trial regimen <24 hours after symptoms onset
  • Reduces viral load 1 day after initiation of medication
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